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Bayer collaborates with DNDi to accelerate the elimination of river blindness in targeted countries of Africa

Bayer collaborates with DNDi to accelerate the elimination of river blindness in targeted countries of Africa

German pharma major Bayer (BAYN: DE) and the Drugs for Neglected Diseases initiative (DNDi) have signed an agreement under which Bayer will provide the active ingredient emodepside to support DNDi in its effort to develop a new oral drug to treat river blindness (or onchocerciasis).

Emodepside originates from the Japanese pharmaceutical company Astellas (TYO: 4503) and has been developed by Bayer HealthCare’s Animal Health division for veterinary use. The compound has been found to be effective in killing adult worms in preclinical studies, thus showing potential as a new ‘macrofilaricidal’ drug for the treatment of patients with river blindness. Astellas has granted Bayer the rights to develop emodepside along these lines.

Large-scale programs for the treatment and control of filarial diseases, such as river blindness, have been in place for over 20 years, based on administering drugs to entire populations. While these mass drug administration (MDA) programs have seen considerable successes, treatments must be repeated at regular intervals of every six or 12 months for up to 17 years to cover the life span of adult worms. This is primarily due to the fact that currently used treatments are ‘microfilaricidal,’ which means that they kill only the young worms. A macrofilaricide such as emodepside, by killing adult worms, could dramatically reduce treatment time of MDAs and could be used in areas and circumstances where the use of microfilaricidal drugs is limited.

Hope to bring a new, safe, short-course, field-adapted treatment to patients

“We need to build on the experience and progress of the past twenty years and give new impetus to research and development for new health tools to accelerate the elimination of river blindness in targeted countries of Africa,” explains Bernard Pécoul, executive director of DNDi, adding: “Through our collaboration with Bayer on the development of emodepside, we hope to bring a new, safe, short-course, field-adapted treatment to patients and  offer a new public health approach for countries long affected by this disease.”

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“The provision of drugs for treating neglected tropical diseases like Chagas disease and African sleeping sickness has been an essential component of our social engagement for many years now,” says Olivier Brandicourt, chairman of the board of management of Bayer HealthCare.

Within the framework of the agreement, DNDi will be responsible for the preclinical and clinical development of emodepside and Bayer for the pharmaceutical development, manufacturing, registration and supply of the drug. The agreement ensures that emodepside, if successful in subsequent phases of drug development, would be available at the lowest sustainable price to ensure affordability and access in the current 31 African disease-endemic countries.

The rights to use technology or data generated within the collaboration allow each party to pursue the project with third partners in case of withdrawal of the other party, thus securing the development and accessibility of emodepside for the benefit of patients.

Source: ww.thepharmaletter.com

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